Structure-activity relationship studies on the macrolide exotoxin mycolactone of Mycobacterium ulcerans.

• Main Authors: Nicole Scherr (Author), Philipp Gersbach (Author), Jean-Pierre Dangy (Author), Claudio Bomio (Author), Jun Li (Author), Karl-Heinz Altmann (Author), Gerd Pluschke (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Mycolactones are a family of polyketide-derived macrolide exotoxins produced by Mycobacterium ulcerans, the causative agent of the chronic necrotizing skin disease Buruli ulcer. The toxin is synthesized by polyketide synthases encoded by the virulence plasmid pMUM. The apoptotic, necroti...