Mechanochemical prepared ibuprofen-Polygonatum sibiricum polysaccharide drug delivery system for enhanced bioactivity with reduced renal injury induced by NSAIDs

• Main Authors: Wenhao Xu (Author), Jinli Yang (Author), Xiangyang Gu (Author), Wenjing Su (Author), Faxiang Pu (Author), Zhangfu Xie (Author), Kongliang Jin (Author), Weike Su (Author), Lichan Mao (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ibuprofen (IBU) was a widely used NSAID (a type of nonsteroidal anti-inflammatory drug) worldwide, and many drug deliveries had been reported to enhance bioavailability. However, higher bioavailability would increase the danger of renal injury caused by oxidative stress. This study prepared IBU-Poly...