Inhibition of Mitochondrial Uncoupling Proteins Arrests Human Spermatozoa Motility without Compromising Viability

• Egile Nagusiak: David F. Carrageta (Egilea), Laís Freire-Brito (Egilea), Bárbara Guerra-Carvalho (Egilea), João C. Ribeiro (Egilea), Bruno S. Monteiro (Egilea), Alberto Barros (Egilea), Pedro F. Oliveira (Egilea), Mariana P. Monteiro (Egilea), Marco G. Alves (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2023-02-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Mitochondrial uncoupling proteins (UCPs) are central in the regulation of mitochondrial activity and reactive oxygen species (ROS) production. High oxidative stress is a major cause of male infertility; however, UCPs expression and function in human spermatozoa are still unknown. Herein, we aimed to...