Feasibility of Developing Radiotracers for MDM2: Synthesis and Preliminary Evaluation of an ¹⁸F-Labeled Analogue of the MDM2 Inhibitor SP-141

• Main Authors: Satish K. Chitneni (Author), Zhengyuan Zhou (Author), Brian E. Watts (Author), Michael R. Zalutsky (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Murine double minute 2 (MDM2), a negative regulator of the p53 tumor suppressor protein, is overexpressed in several human cancers. Herein we investigate the feasibility of developing ¹⁸F-labeled compounds based on the small molecule inhibitor SP-141 for imaging tumor MDM2 exp...