PD-1 gene polymorphisms and thyroid expression of PD-1 ligands differ between Graves' and Hashimoto's diseases

• Auteurs principaux: Mayumi Kawabata (Auteur), Naoya Inoue (Auteur), Mikio Watanabe (Auteur), Ayaka Kobayashi (Auteur), Yoh Hidaka (Auteur), Akira Miyauchi (Auteur), Yoshinori Iwatani (Auteur)
• Format: Livre
• Publié: Taylor & Francis Group, 2021-10-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

The programmed cell death-1 (PD-1)/PD ligand pathway plays a key role in the maintenance of peripheral tolerance by enhancing the suppressive activity of regulatory T (Treg) cells. The promoter activity of the A allele of PD1 rs36084323 G/A polymorphism is lower than that of the G allele. We examine...