PD-1 gene polymorphisms and thyroid expression of PD-1 ligands differ between Graves' and Hashimoto's diseases

• Main Authors: Mayumi Kawabata (Author), Naoya Inoue (Author), Mikio Watanabe (Author), Ayaka Kobayashi (Author), Yoh Hidaka (Author), Akira Miyauchi (Author), Yoshinori Iwatani (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The programmed cell death-1 (PD-1)/PD ligand pathway plays a key role in the maintenance of peripheral tolerance by enhancing the suppressive activity of regulatory T (Treg) cells. The promoter activity of the A allele of PD1 rs36084323 G/A polymorphism is lower than that of the G allele. We examine...