Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes

• Main Authors: Andreea-Manuela Mirea (Author), Erik J. M. Toonen (Author), Inge van den Munckhof (Author), Isabelle D. Munsterman (Author), Eric T. T. L. Tjwa (Author), Martin Jaeger (Author), Marije Oosting (Author), Kiki Schraa (Author), Joost H. W. Rutten (Author), Marinette van der Graaf (Author), Niels P. Riksen (Author), Jacqueline de Graaf (Author), Mihai G. Netea (Author), Cees J. Tack (Author), Triantafyllos Chavakis (Author), Leo A. B. Joosten (Author)
• Format: Book
• Published: BMC, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Introduction Non-alcoholic fatty liver disease (NAFLD) is becoming a major health problem worldwide. Inflammation plays an important role in disease pathogenesis and recent studies have shown a potential role for the neutrophil serine proteases (NSPs) proteinase-3 (PR3) and neutrophil elast...