Synthesis and biological activity evaluation of 3-(hetero) arylideneindolin-2-ones as potential c-Src inhibitors

• Main Authors: Salvatore Princiotto (Author), Loana Musso (Author), Fabrizio Manetti (Author), Valentina Marcellini (Author), Giovanni Maga (Author), Emmanuele Crespan (Author), Cecilia Perini (Author), Nadia Zaffaroni (Author), Giovanni Luca Beretta (Author), Sabrina Dallavalle (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inhibition of c-Src is considered one of the most studied approaches to cancer treatment, with several heterocyclic compounds approved during the last 15 years as chemotherapeutic agents. Starting from the biological evaluation of an in-house collection of small molecules, indolinone was selected as...