Genome-wide functional perturbation of human microsatellite repeats using engineered zinc finger transcription factors

• Main Authors: Y. Esther Tak (Author), Gaylor Boulay (Author), Lukuo Lee (Author), Sowmya Iyer (Author), Nicholas T. Perry (Author), Hayley T. Schultz (Author), Sara P. Garcia (Author), Liliane Broye (Author), Joy E. Horng (Author), Shruthi Rengarajan (Author), Beverly Naigles (Author), Angela Volorio (Author), Jeffry D. Sander (Author), Jingyi Gong (Author), Nicolò Riggi (Author), J. Keith Joung (Author), Miguel N. Rivera (Author)
• Format: Book
• Published: Elsevier, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Repeat elements can be dysregulated at a genome-wide scale in human diseases. For example, in Ewing sarcoma, hundreds of inert GGAA repeats can be converted into active enhancers when bound by EWS-FLI1. Here we show that fusions between EWS and GGAA-repeat-targeted engineered zinc finger ar...