Enhancement of Skin Permeability Prediction through PBPK Modeling, Bayesian Inference, and Experiment Design

• Hoofdauteurs: Abdullah Hamadeh (Auteur), Abdulkarim Najjar (Auteur), John Troutman (Auteur), Andrea Edginton (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2023-11-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Physiologically based pharmacokinetic (PBPK) models of skin absorption are a powerful resource for estimating drug delivery and chemical risk of dermatological products. This paper presents a PBPK workflow for the quantification of the mechanistic determinants of skin permeability and the use of the...