Nrf2 regulates downstream genes by targeting miR-29b in severe asthma and the role of grape seed proanthocyanidin extract in a murine model of steroid-insensitive asthma

• Main Authors: Yan Qian (Author), Yun Sun (Author), Yi Chen (Author), Zhengdao Mao (Author), Yujia Shi (Author), Di Wu (Author), Bin Gu (Author), Zhiguang Liu (Author), Qian Zhang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Context Grape seed proanthocyanidin extract (GSPE) is effective in treating severe asthma (SA). Objective To examine the relationship between Nrf2-miR-29b axis and SA, and to detect whether preventive use of GSPE relieves SA via it. Materials and methods We recruited 10 healthy controls, 10 patients...