A Physiologically Based Pharmacokinetic Model to Predict Systemic Ondansetron Concentration in Liver Cirrhosis Patients

• Main Authors: Faleh Alqahtani (Author), Abdullah H. Alruwaili (Author), Mohammed S. Alasmari (Author), Sultan A. Almazroa (Author), Khaled S. Alsuhaibani (Author), Muhammad F. Rasool (Author), Abdulkarim F. Alruwaili (Author), Sary Alsanea (Author)
• Format: Book
• Published: MDPI AG, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Ondansetron is a drug that is routinely prescribed for the management of nausea and vomiting associated with cancer, radiation therapy, and surgical operations. It is mainly metabolized in the liver, and it might accumulate in patients with hepatic impairment and lead to unwanted adver...