Integrin αVβ3 antagonist-c(RGDyk) peptide attenuates the progression of ossification of the posterior longitudinal ligament by inhibiting osteogenesis and angiogenesis

• Main Authors: Xiangwu Geng (Author), Yifan Tang (Author), Changjiang Gu (Author), Junkai Zeng (Author), Yin Zhao (Author), Quanwei Zhou (Author), Lianshun Jia (Author), Shengyuan Zhou (Author), Xiongsheng Chen (Author)
• Format: Book
• Published: BMC, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Ossification of the posterior longitudinal ligament (OPLL), an emerging heterotopic ossification disease, causes spinal cord compression, resulting in motor and sensory dysfunction. The etiology of OPLL remains unclear but may involve integrin αVβ3 regulating the process of osteo...