Expression of the Metalloproteinase ADAM8 Is Upregulated in Liver Inflammation Models and Enhances Cytokine Release In Vitro

• Main Authors: Tanzeela Awan (Author), Aaron Babendreyer (Author), Justyna Wozniak (Author), Abid Mahmood Alvi (Author), Viktor Sterzer (Author), Lena Cook (Author), Jörg W. Bartsch (Author), Christian Liedtke (Author), Daniela Yildiz (Author), Andreas Ludwig (Author)
• Format: Book
• Published: Hindawi Limited, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acute and chronic liver inflammation is driven by cytokine and chemokine release from various cell types in the liver. Here, we report that the induction of inflammatory mediators is associated with a yet undescribed upregulation of the metalloproteinase ADAM8 in different murine hepatitis models. W...