Long-Distance Phasing of a Tentative "Enhancer" Single-Nucleotide Polymorphism With CYP2D6 Star Allele Definitions

• Hauptverfasser: Erin C. Boone (Verfasst von), Wendy Y. Wang (Verfasst von), Roger Gaedigk (Verfasst von), Mariana Cherner (Verfasst von), Anick Bérard (Verfasst von), J. Steven Leeder (Verfasst von), Neil A. Miller (Verfasst von), Andrea Gaedigk (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2020-05-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

BackgroundThe CYP2D6 gene locus has been extensively studied over decades, yet a portion of variability in CYP2D6 activity cannot be explained by known sequence variations within the gene, copy number variation, or structural rearrangements. It was proposed that rs5758550, located 116 kb downstream...