Improving Breast Cancer Treatment Specificity Using Aptamers Obtained by 3D Cell-SELEX

• Glavni autori: Frank H. T. Nelissen (Autor), Wenny J. M. Peeters (Autor), Timo P. Roelofs (Autor), Anika Nagelkerke (Autor), Paul N. Span (Autor), Hans A. Heus (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2021-04-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Three-dimensional spheroids of non-malignant MCF10A and malignant SKBR3 breast cells were used for subsequent 3D Cell-SELEX to generate aptamers for specific binding and treatment of breast cancer cells. Using 3D Cell-SELEX combined with Next-Generation Sequencing and bioinformatics, ten abundant ap...