Improving Breast Cancer Treatment Specificity Using Aptamers Obtained by 3D Cell-SELEX

• Main Authors: Frank H. T. Nelissen (Author), Wenny J. M. Peeters (Author), Timo P. Roelofs (Author), Anika Nagelkerke (Author), Paul N. Span (Author), Hans A. Heus (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Three-dimensional spheroids of non-malignant MCF10A and malignant SKBR3 breast cells were used for subsequent 3D Cell-SELEX to generate aptamers for specific binding and treatment of breast cancer cells. Using 3D Cell-SELEX combined with Next-Generation Sequencing and bioinformatics, ten abundant ap...