Inhibition of XPO-1 Mediated Nuclear Export through the Michael-Acceptor Character of Chalcones
The nuclear export receptor exportin-1 (XPO1, CRM1) mediates the nuclear export of proteins that contain a leucine-rich nuclear export signal (NES) towards the cytoplasm. XPO1 is considered a relevant target in different human diseases, particularly in hematological malignancies, tumor resistance, i...
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MDPI AG,
2021-11-01T00:00:00Z.
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