Inhibition of XPO-1 Mediated Nuclear Export through the Michael-Acceptor Character of Chalcones

• Main Authors: Marta Gargantilla (Author), José López-Fernández (Author), Maria-Jose Camarasa (Author), Leentje Persoons (Author), Dirk Daelemans (Author), Eva-Maria Priego (Author), María-Jesús (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The nuclear export receptor exportin-1 (XPO1, CRM1) mediates the nuclear export of proteins that contain a leucine-rich nuclear export signal (NES) towards the cytoplasm. XPO1 is considered a relevant target in different human diseases, particularly in hematological malignancies, tumor resistance, i...