Development of novel ultra-sensitive IL-11 target engagement assays to support mechanistic PK/PD modeling for an anti-IL-11 antibody therapeutic

• Main Authors: Maria Myzithras (Author), Siqi Lin (Author), Legairre Radden (Author), Cynthia Hess Kenny (Author), Zheng Cai (Author), Angus MacDonald (Author), Ralph Binetti (Author), Michael Marlow (Author), Paul Fracasso (Author), Glenn Gibson (Author), Christina Bartlett (Author), Julie Hawkins (Author), Steven Hansel (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

An in-house antibody generation campaign identified a diverse, high affinity set of anti-interleukin-11 (IL-11) monoclonal antibodies (mAbs) to enable successful development of novel, custom ultra-sensitive target engagement assays for detection of "free" (unbound to the dosed anti-IL-11 t...