Non-covalent immunoproteasome inhibitors induce cell cycle arrest in multiple myeloma MM.1R cells

• मुख्य लेखकों: Roberta Ettari (लेखक), Giovanni Pallio (लेखक), Gabriele Pizzino (लेखक), Natasha Irrera (लेखक), Maria Zappalà (लेखक), Santina Maiorana (लेखक), Carla Di Chio (लेखक), Domenica Altavilla (लेखक), Francesco Squadrito (लेखक), Alessandra Bitto (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Proteasome inhibition is a promising strategy for the treatment of multiple myeloma; unfortunately, this disease is often associated with an increasing chemoresistance. One novel approach may be to target the immunoproteasome, a proteasomal isoform mainly present in cells of hematopoietic origin. We...