Non-covalent immunoproteasome inhibitors induce cell cycle arrest in multiple myeloma MM.1R cells

• Main Authors: Roberta Ettari (Author), Giovanni Pallio (Author), Gabriele Pizzino (Author), Natasha Irrera (Author), Maria Zappalà (Author), Santina Maiorana (Author), Carla Di Chio (Author), Domenica Altavilla (Author), Francesco Squadrito (Author), Alessandra Bitto (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Proteasome inhibition is a promising strategy for the treatment of multiple myeloma; unfortunately, this disease is often associated with an increasing chemoresistance. One novel approach may be to target the immunoproteasome, a proteasomal isoform mainly present in cells of hematopoietic origin. We...