Weak complexation of 5-fluorouracil with β-cyclodextrin, carbonate, and dianhydride crosslinked β-cyclodextrin: in vitro and in silico studies

• Główni autorzy: Hadeia Mashaqbeh (Autor), Rana Obaidat (Autor), Nizar A Al-Shar'i (Autor), Tamam El-Elimat (Autor), Soraya Alnabulsi (Autor)
• Format: Książka
• Wydane: Wolters Kluwer Medknow Publications, 2022-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Background and purpose: Several pharmaceutical formulations were investigated to improve the solubility of 5-fluorouracil to enhance bioavailability and therapeutic efficacy. This study aimed to examine the potential use of cyclodextrin-based nanosponges for the incorporation of 5-fluorouracil and t...