Identification of imidazo[4,5-c]pyridin-2-one derivatives as novel Src family kinase inhibitors against glioblastoma

• Main Authors: Lishun Zhang (Author), Zichao Yang (Author), Huiting Sang (Author), Ying Jiang (Author), Mingfeng Zhou (Author), Chuan Huang (Author), Chunhui Huang (Author), Xiaoyun Wu (Author), Tingting Zhang (Author), Xingmei Zhang (Author), Shanhe Wan (Author), Jiajie Zhang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glioblastoma multiforme (GBM) is the most common and malignant primary brain tumour in the central nervous system (CNS). As the ideal targets for GBM treatment, Src family kinases (SFKs) have attracted much attention. Herein, a new series of imidazo[4,5-c]pyridin-2-one derivatives were designed and...