Methylprednisolone Administration Following Spinal Cord Injury Reduces Aquaporin 4 Expression and Exacerbates Edema

• Main Authors: Eibar Ernesto Cabrera-Aldana (Author), Fernando Ruelas (Author), Cristina Aranda (Author), Ruth Rincon-Heredia (Author), Angelina Martínez-Cruz (Author), Alejandro Reyes-Sánchez (Author), Gabriel Guizar-Sahagún (Author), Luis B. Tovar- (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Spinal cord injury (SCI) is an incapacitating condition that affects motor, sensory, and autonomic functions. Since 1990, the only treatment administered in the acute phase of SCI has been methylprednisolone (MP), a synthetic corticosteroid that has anti-inflammatory effects; however, its efficacy r...