Lupus Nephritis: Enigmas, Conflicting Models and an Emerging Concept

Abstract Autoantibodies to components of chromatin, which include double-stranded DNA (dsDNA), histones and nucleosomes, are central in the pathogenesis of lupus nephritis. How anti-chromatin autoantibodies exert their nephritogenic activity, however, is controversial. One model assumes that autoant...

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Autores principales: Natalya Seredkina (Autor), Johan van der Vlag (Autor), Jo Berden (Autor), Elin Mortensen (Autor), Ole Petter Rekvig (Autor)
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Publicado: BMC, 2013-06-01T00:00:00Z.
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