Ruscogenin alleviates LPS-triggered pulmonary endothelial barrier dysfunction through targeting NMMHC IIA to modulate TLR4 signaling

• 主要な著者: Yunhao Wu (著者), Xiu Yu (著者), Yuwei Wang (著者), Yalin Huang (著者), Jiahui Tang (著者), Shuaishuai Gong (著者), Siyu Jiang (著者), Yuanli Xia (著者), Fang Li (著者), Boyang Yu (著者), Yuanyuan Zhang (著者), Junping Kou (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2022-03-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Pulmonary endothelial barrier dysfunction is a hallmark of clinical pulmonary edema and contributes to the development of acute lung injury (ALI). Here we reported that ruscogenin (RUS), an effective steroidal sapogenin of Radix Ophiopogon japonicus, attenuated lipopolysaccharides (LPS)-induced pulm...