Ruscogenin alleviates LPS-triggered pulmonary endothelial barrier dysfunction through targeting NMMHC IIA to modulate TLR4 signaling

• Main Authors: Yunhao Wu (Author), Xiu Yu (Author), Yuwei Wang (Author), Yalin Huang (Author), Jiahui Tang (Author), Shuaishuai Gong (Author), Siyu Jiang (Author), Yuanli Xia (Author), Fang Li (Author), Boyang Yu (Author), Yuanyuan Zhang (Author), Junping Kou (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pulmonary endothelial barrier dysfunction is a hallmark of clinical pulmonary edema and contributes to the development of acute lung injury (ALI). Here we reported that ruscogenin (RUS), an effective steroidal sapogenin of Radix Ophiopogon japonicus, attenuated lipopolysaccharides (LPS)-induced pulm...