Effective Prevention of Liver Fibrosis by Liver-targeted Hydrodynamic Gene Delivery of Matrix Metalloproteinase-13 in a Rat Liver Fibrosis Model

• Main Authors: Hiroyuki Abe (Author), Kenya Kamimura (Author), Yuji Kobayashi (Author), Masato Ohtsuka (Author), Hiromi Miura (Author), Riuko Ohashi (Author), Takeshi Yokoo (Author), Tsutomu Kanefuji (Author), Takeshi Suda (Author), Masanori Tsuchida (Author), Yutaka Aoyagi (Author), Guisheng Zhang (Author), Dexi Liu (Author), Shuji Terai (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Liver fibrosis is the final stage of liver diseases that lead to liver failure and cancer. While various diagnostic methods, including the use of serum marker, have been established, no standard therapy has been developed. The objective of this study was to assess the approach of overexpressing matr...