Exploring the Effect of Compound Glycyrrhizin and Silybinin on the Metabolism of Pexidartinib in Rats Based on CYP3A4 and CYP2C9

• Main Authors: Yanding Su (Author), Xinyi Wei (Author), Qian Cheng (Author), He Qi (Author), Jianghui Chen (Author), Xiang-Jun Qiu (Author)
• Format: Bog
• Udgivet: Hindawi Limited, 2023-01-01T00:00:00Z.
• Fag: article
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Pexidartinib offered a new therapeutic option for adult patients with symptomatic tenosynovial giant cell tumor (TGCT) who were refractory to surgical treatment and had severe morbidity or functional limitations. Meanwhile, the metabolism of pexidartinib was mainly mediated through the oxidation of...