Synergistic Effects of Adenosine A2A Antagonist and L-DOPA on Rotational Behaviors in 6-Hydroxydopamine-Induced Hemi-Parkinsonian Mouse Model

• Main Authors: Takahiro Matsuya (Author), Kazuhiro Takuma (Author), Kosuke Sato (Author), Makoto Asai (Author), Yoshihiro Murakami (Author), Sosuke Miyoshi (Author), Akihiro Noda (Author), Taku Nagai (Author), Hiroyuki Mizoguchi (Author), Shintaro Nishimura (Author), Kiyofumi Yamada (Author)
• Format: Book
• Published: Elsevier, 2007-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, we examined the combination effects of L-DOPA and adenosine receptor antagonists on rotational behaviors in a hemi-Parkinsonian mouse model induced by unilateral 6-hydroxydopamine (6-OHDA) injection. The adenosine A2A antagonist SCH-58261, but not the A1-receptor antagonist 8-cyclopen...