Comparative analyses of downstream signal transduction targets modulated after activation of the AT1 receptor by two β-arrestin biased agonists

• Main Authors: Geisa A Santos (Author), Diego A Duarte (Author), Lucas T Parreiras- (Author), Felipe R Teixeira (Author), Rafael M Silva-Rocha (Author), Eduardo B Oliveira (Author), Michel eBouvier (Author), Claudio M Costa-Neto (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

G protein-coupled receptors (GPCRs) are involved in essentially all physiological processes in mammals. The classical GPCR signal transduction mechanism occurs by coupling to G protein, but it has recently been demonstrated that interaction with β-arrestins leads to activation of pathways that are i...