Properties of a Novel GABAA Receptor γ2 Subunit Mutation Associated With Seizures

• Main Authors: Keisuke Migita (Author), Junko Yamada (Author), Yoshikazu Nikaido (Author), XiuYu Shi (Author), Sunao Kaneko (Author), Shinichi Hirose (Author), Shinya Ueno (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We recently identified a novel missense mutation of the γ2 subunit at position 40 with serine (N40S) of the GABAA receptor from a patient with epilepsy. Here, we report properties of the mutant receptor using the whole cell patch clamp technique. The Hill coefficient for the N40S receptor was greate...