cAMP driven UCP1 induction in human adipocytes requires ATGL-catalyzed lipolysis

• Main Authors: Anand Desai (Author), Zinger Yang Loureiro (Author), Tiffany DeSouza (Author), Qin Yang (Author), Javier Solivan-Rivera (Author), Silvia Corvera (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The uncoupling protein 1 (UCP1) is induced in brown or "beige" adipocytes through catecholamine-induced cAMP signaling, which activates diverse transcription factors. UCP1 expression can also be enhanced by PPARγ agonists such as rosiglitazone (Rsg). However, it is unclear wheth...