The Artemiside-Artemisox-Artemisone-M1 Tetrad: Efficacies against Blood Stage <i>P. falciparum</i> Parasites, DMPK Properties, and the Case for Artemiside

• Main Authors: Liezl Gibhard (Author), Dina Coertzen (Author), Janette Reader (Author), Mariëtte E. van der Watt (Author), Lyn-Marie Birkholtz (Author), Ho Ning Wong (Author), Kevin T. Batty (Author), Richard K. Haynes (Author), Lubbe Wiesner (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Because of the need to replace the current clinical artemisinins in artemisinin combination therapies, we are evaluating fitness of amino-artemisinins for this purpose. These include the thiomorpholine derivative artemiside obtained in one scalable synthetic step from dihydroartemisinin (DHA) and th...