The Artemiside-Artemisox-Artemisone-M1 Tetrad: Efficacies against Blood Stage <i>P. falciparum</i> Parasites, DMPK Properties, and the Case for Artemiside

• Egile Nagusiak: Liezl Gibhard (Egilea), Dina Coertzen (Egilea), Janette Reader (Egilea), Mariëtte E. van der Watt (Egilea), Lyn-Marie Birkholtz (Egilea), Ho Ning Wong (Egilea), Kevin T. Batty (Egilea), Richard K. Haynes (Egilea), Lubbe Wiesner (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2021-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Because of the need to replace the current clinical artemisinins in artemisinin combination therapies, we are evaluating fitness of amino-artemisinins for this purpose. These include the thiomorpholine derivative artemiside obtained in one scalable synthetic step from dihydroartemisinin (DHA) and th...