Chotosan, a Kampo Formula, Ameliorates Hippocampal LTD and Cognitive Deficits in Juvenile-Onset Diabetes Rats

• Main Authors: Sachie Sasaki-Hamada (Author), Keita Tamaki (Author), Hayuma Otsuka (Author), Tatsuto Ueno (Author), Hiroaki Sacai (Author), Yimin Niu (Author), Kinzo Matsumoto (Author), Jun-Ichiro Oka (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Childhood-onset type 1 diabetes is associated with modest impairments in cognition and has an elevated risk of cognitive decline. Our previous study showed that working memory and hippocampal long-term depression (LTD) were impaired in juvenile-onset diabetes mellitus (JDM) rats. In this study, we i...