Impact of SLCO1B1 Genetic Variation on Rosuvastatin Systemic Exposure in Pediatric Hypercholesterolemia

• Main Authors: Jonathan B. Wagner (Author), Susan Abdel‐Rahman (Author), Andrea Gaedigk (Author), Roger Gaedigk (Author), Geetha Raghuveer (Author), Vincent S. Staggs (Author), Leon Van Haandel (Author), J. Steven Leeder (Author)
• Format: Book
• Published: Wiley, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study investigated the impact of SLCO1B1 genotype on rosuvastatin systemic exposure in hypercholesterolemic children and adolescents. Participants (8-21 years) with at least one allelic variant of SLCO1B1 c.521T>C (521TC, n = 13; 521CC, n = 2) and wild type controls (521TT, n = 13) completed...