The Depolarization-Evoked, Ca2+-Dependent Release of Exosomes From Mouse Cortical Nerve Endings: New Insights Into Synaptic Transmission

• Main Authors: Guendalina Olivero (Author), Francesca Cisani (Author), Danilo Marimpietri (Author), Daniela Di Paolo (Author), Maria Cristina Gagliani (Author), Marina Podestà (Author), Katia Cortese (Author), Anna Pittaluga (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Whether exosomes can be actively released from presynaptic nerve terminals is a matter of debate. To address the point, mouse cortical synaptosomes were incubated under basal and depolarizing (25 mM KCl-enriched medium) conditions, and extracellular vesicles were isolated from the synaptosomal super...