Profiling the Mismatch Tolerance of Argonaute 2 through Deep Sequencing of Sliced Polymorphic Viral RNAs

• Auteurs principaux: Pantazis I. Theotokis (Auteur), Louise Usher (Auteur), Christopher K. Kortschak (Auteur), Ed Schwalbe (Auteur), Sterghios A. Moschos (Auteur)
• Format: Livre
• Publié: Elsevier, 2017-12-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Low allelic and clonal variability among endogenous RNAi targets has focused mismatch tolerance studies to RNAi-active guide strands. However, the inherent genomic instability of RNA viruses such as hepatitis C virus (HCV) gives rise to quasi-species mutants within discrete clones: this facilitates...