Profiling the Mismatch Tolerance of Argonaute 2 through Deep Sequencing of Sliced Polymorphic Viral RNAs

• Autores principales: Pantazis I. Theotokis (Autor), Louise Usher (Autor), Christopher K. Kortschak (Autor), Ed Schwalbe (Autor), Sterghios A. Moschos (Autor)
• Formato: Libro
• Publicado: Elsevier, 2017-12-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Low allelic and clonal variability among endogenous RNAi targets has focused mismatch tolerance studies to RNAi-active guide strands. However, the inherent genomic instability of RNA viruses such as hepatitis C virus (HCV) gives rise to quasi-species mutants within discrete clones: this facilitates...