Potent Anti-seizure Effects of Locked Nucleic Acid Antagomirs Targeting miR-134 in Multiple Mouse and Rat Models of Epilepsy

• Main Authors: Cristina R. Reschke (Author), Luiz F. Almeida Silva (Author), Braxton A. Norwood (Author), Ketharini Senthilkumar (Author), Gareth Morris (Author), Amaya Sanz-Rodriguez (Author), Ronán M. Conroy (Author), Lara Costard (Author), Valentin Neubert (Author), Sebastian Bauer (Author), Michael A. Farrell (Author), Donncha F. O'Brien (Author), Norman Delanty (Author), Stephanie Schorge (Author), R. Jeroen Pasterkamp (Author), Felix Rosenow (Author), David C. Henshall (Author)
• Format: Book
• Published: Elsevier, 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Current anti-epileptic drugs (AEDs) act on a limited set of neuronal targets, are ineffective in a third of patients with epilepsy, and do not show disease-modifying properties. MicroRNAs are small noncoding RNAs that regulate levels of proteins by post-transcriptional control of mRNA stability and...