Potent Anti-seizure Effects of Locked Nucleic Acid Antagomirs Targeting miR-134 in Multiple Mouse and Rat Models of Epilepsy

Current anti-epileptic drugs (AEDs) act on a limited set of neuronal targets, are ineffective in a third of patients with epilepsy, and do not show disease-modifying properties. MicroRNAs are small noncoding RNAs that regulate levels of proteins by post-transcriptional control of mRNA stability and...

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Main Authors: Cristina R. Reschke (Author), Luiz F. Almeida Silva (Author), Braxton A. Norwood (Author), Ketharini Senthilkumar (Author), Gareth Morris (Author), Amaya Sanz-Rodriguez (Author), Ronán M. Conroy (Author), Lara Costard (Author), Valentin Neubert (Author), Sebastian Bauer (Author), Michael A. Farrell (Author), Donncha F. O'Brien (Author), Norman Delanty (Author), Stephanie Schorge (Author), R. Jeroen Pasterkamp (Author), Felix Rosenow (Author), David C. Henshall (Author)
Format: Book
Published: Elsevier, 2017-03-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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