Selective degradation of hyperphosphorylated tau by proteolysis-targeting chimeras ameliorates cognitive function in Alzheimer's disease model mice

• Main Authors: Dongping Yao (Author), Ting Li (Author), Lu Yu (Author), Mingxing Hu (Author), Ye He (Author), Ruiming Zhang (Author), Junjie Wu (Author), Shuoyuan Li (Author), Weihong Kuang (Author), Xifei Yang (Author), Gongping Liu (Author), Yongmei Xie (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alzheimer's disease (AD) is one of the most common chronic neurodegenerative diseases. Hyperphosphorylated tau plays an indispensable role in neuronal dysfunction and synaptic damage in AD. Proteolysis-targeting chimeras (PROTACs) are a novel type of chimeric molecule that can degrade target pr...