suz12 inactivation in p53- and nf1-deficient zebrafish accelerates the onset of malignant peripheral nerve sheath tumors and expands the spectrum of tumor types

• Main Authors: Felix Oppel (Author), Dong H. Ki (Author), Mark W. Zimmerman (Author), Kenneth N. Ross (Author), Ting Tao (Author), Hui Shi (Author), Shuning He (Author), Jon C. Aster (Author), A. Thomas Look (Author)
• Format: Book
• Published: The Company of Biologists, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Polycomb repressive complex 2 (PRC2) is an epigenetic regulator of gene expression that possesses histone methyltransferase activity. PRC2 trimethylates lysine 27 of histone H3 proteins (H3K27me3) as a chromatin modification associated with repressed transcription of genes frequently involved in cel...