Baicalein Enhances the Oral Bioavailability and Hepatoprotective Effects of Silybin Through the Inhibition of Efflux Transporters BCRP and MRP2

Although hepatoprotective properties of silybin are well documented, the clinical therapeutic efficacy is limited by its low bioavailability due to absorption rates, extensive phase II metabolism, and biliary excretion. As our previous study indicated that metabolic enzymes may have limited effects...

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Main Authors: Peng Xu (Author), Hua Zhou (Author), Ya-Zhuo Li (Author), Zhong-Wen Yuan (Author), Chang-Xiao Liu (Author), Liang Liu (Author), Ying Xie (Author)
Format: Book
Published: Frontiers Media S.A., 2018-10-01T00:00:00Z.
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