Clinical pharmacokinetics of methotrexate in the treatment of acute lymphoblastic leukemia and non-Hodgkin lymphoma in pediatric patients

• Hlavní autoři: Škorić Biljana (Autor), Jovanović Marija (Autor), Miljković Branislava (Autor), Kuzmanović Miloš (Autor), Vučićević Katarina (Autor)
• Médium: Kniha
• Vydáno: Pharmaceutical Association of Serbia, Belgrade, Serbia, 2020-01-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

High dose methotrexate (MTX) is used in therapy of acute lymphoblastic leukemia and non-Hodgkin lymphoma in pediatric patients. It acts as competitive inhibitor of dihydrofolate reductase and consequently inhibits synthesis of deoxyribonucleic acid. The bioavailability is dependent upon dose and rou...