Clinical pharmacokinetics of methotrexate in the treatment of acute lymphoblastic leukemia and non-Hodgkin lymphoma in pediatric patients
High dose methotrexate (MTX) is used in therapy of acute lymphoblastic leukemia and non-Hodgkin lymphoma in pediatric patients. It acts as competitive inhibitor of dihydrofolate reductase and consequently inhibits synthesis of deoxyribonucleic acid. The bioavailability is dependent upon dose and rou...
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| Main Authors: | , , , , |
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| Format: | Book |
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Pharmaceutical Association of Serbia, Belgrade, Serbia,
2020-01-01T00:00:00Z.
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