Effect of NLRP3 inflammasome induced astrocyte phenotype alteration in morphine tolerance

• Main Authors: Zhenyu Yuan (Author), Boxuan Lu (Author), Meiling Zhang (Author), Yinxiao Lu (Author), Zhihui Wang (Author), Wenhao Zhang (Author), Hao Cheng (Author), Zhifang Wu (Author), Qing Ji (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IntroductionMorphine is a widely used analgesic, but its prolonged use often leads to tolerance, limiting its therapeutic efficacy. Research implicates the NLRP3 inflammasome and reactive astrocytes in the development of morphine tolerance, with reactive astrocytes classified into A1 neurotoxic and...