Pharmacokinetics and Anti-asthmatic Potential of Non-parenterally Administered Recombinant Human Interleukin-1 Receptor Antagonist in Animal Models

• Main Authors: Ting Li (Author), Wan-Liang Lu (Author), Hai-Yan Hong (Author), Yan-Sheng Yao (Author), Pu Han (Author), Zhong-Kun Li (Author), Gui-Ling Wang (Author), Yi Cao (Author), Xiang-Rui Liu (Author), Jian-Cheng Wang (Author), Xuan Zhang (Author), Qiang Zhang (Author)
• Format: Book
• Published: Elsevier, 2006-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The objectives of this study were to define the pharmacokinetics of recombinant human interleukin-1 receptor antagonist (rhIL-1ra) and its effects on allergic asthma, cell adhesion molecules, and upper respiratory tract following non-parenteral administration in animals. Pharmacokinetics and immunom...