Structure of human GPR119-Gs complex binding APD597 and characterization of GPR119 binding agonists

• Main Authors: Ruixue Li (Author), Yuxia Qian (Author), Jiening Wang (Author), Zhen Han (Author), Sheng Ye (Author), Shan Wu (Author), Anna Qiao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The rhodopsin-like receptor GPR119 plays a crucial role in glucose homeostasis and is an emerging target for the treatment of type 2 diabetes mellitus. In this study, we analyzed the structure of GPR119 with the agonist APD597 bound and in complex with the downstream G protein trimer by single parti...