Comorbidity associated to Ascaris suum infection during pulmonary fibrosis exacerbates chronic lung and liver inflammation and dysfunction but not affect the parasite cycle in mice.

• Main Authors: Fabrício Marcus Silva Oliveira (Author), Pablo Hemanoel da Paixão Matias (Author), Lucas Kraemer (Author), Ana Clara Gazzinelli-Guimarães (Author), Flaviane Vieira Santos (Author), Chiara Cássia Oliveira Amorim (Author), Denise Silva Nogueira (Author), Camila Simões Freitas (Author), Marcelo Vidigal Caliari (Author), Daniella Castanheira Bartholomeu (Author), Lilian Lacerda Bueno (Author), Remo Castro Russo (Author), Ricardo Toshio Fujiwara (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ascariasis is considered the most neglected tropical disease, and is a major problem for the public health system. However, idiopathic pulmonary fibrosis (IPF) is a result of chronic extracellular deposition of matrix in the pulmonary parenchyma, and thickening of the alveolar septa, which reduces a...