FORMULATION AND OPTIMIZATION OF PIOGLITAZONE SOLID DISPERSIONS PREPARED BY HOT MELT EXTRUSION TECHNIQUE

• Main Authors: Vidyadhara Suryadevara (Author), Ashis Kumar Mehatha (Author), Sasidhar R Lankapalli (Author), Abhijit M Deshmukh (Author), Laxmana P Sambath (Author)
• Format: Book
• Published: Universitas Gadjah Mada, 2013-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The main objective of the present study was to develop a novel and stable pioglitazone loaded solid dispersions with enhanced solubility and dissolution rate. Different drug-to-carrier ratios were prepared by employing hot melt extrusion technique. These formulations were characterized for solid sta...