In Vitro-In Vivo Correlations Based on In Vitro Dissolution of Parent Drug Diltiazem and Pharmacokinetics of Its Metabolite

• প্রধান লেখক: Constantin Mircioiu (লেখক), Valentina Anuta (লেখক), Ion Mircioiu (লেখক), Adrian Nicolescu (লেখক), Nikoletta Fotaki (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: MDPI AG, 2019-07-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

In this study a novel type of in vitro−in vivo correlation (IVIVC) is proposed: The correlation of the in vitro parent drug dissolution data with the in vivo pharmacokinetic data of drug’s metabolite after the oral administration of the parent drug. The pharmacokinetic data for t...