Stimulation of Hepatic Ferritinophagy Mitigates <i>Irp2</i> Depletion-Induced Anemia

• Glavni autori: Yutong Liu (Autor), Yuxuan Li (Autor), Liu Yang (Autor), Jiaqi Shen (Autor), Hongting Zhao (Autor), Weichen Dong (Autor), Yanzhong Chang (Autor), Tong Qiao (Autor), Kuanyu Li (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2023-02-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Background: Iron regulatory proteins (IRPs) maintain cellular iron homeostasis. Due to aberrant tissue-iron distribution, <i>Irp2</i>-deficient mice suffer microcytic anemia and neurodegeneration, while iron overload occurs in the liver and intestine. We previously found that <i>Ir...