Stimulation of Hepatic Ferritinophagy Mitigates <i>Irp2</i> Depletion-Induced Anemia

• Main Authors: Yutong Liu (Author), Yuxuan Li (Author), Liu Yang (Author), Jiaqi Shen (Author), Hongting Zhao (Author), Weichen Dong (Author), Yanzhong Chang (Author), Tong Qiao (Author), Kuanyu Li (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Iron regulatory proteins (IRPs) maintain cellular iron homeostasis. Due to aberrant tissue-iron distribution, <i>Irp2</i>-deficient mice suffer microcytic anemia and neurodegeneration, while iron overload occurs in the liver and intestine. We previously found that <i>Ir...