Intravital microscopy of collective invasion plasticity in breast cancer

• Main Authors: Olga Ilina (Author), Leonard Campanello (Author), Pavlo G. Gritsenko (Author), Manon Vullings (Author), Chenlu Wang (Author), Peter Bult (Author), Wolfgang Losert (Author), Peter Friedl (Author)
• Format: Book
• Published: The Company of Biologists, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cancer invasion programs are adaptive by switching between metastatic collective and single-cell dissemination; however, current intravital microscopy models for epithelial cancer in mice fail to reliably recreate such invasion plasticity. Using microimplantation of breast cancer spheroids into the...