WSB1 regulates c-Myc expression through β-catenin signaling and forms a feedforward circuit

• Main Authors: Xiaomeng Gao (Author), Jieqiong You (Author), Yanling Gong (Author), Meng Yuan (Author), Haiying Zhu (Author), Liang Fang (Author), Hong Zhu (Author), Meidan Ying (Author), Qiaojun He (Author), Bo Yang (Author), Ji Cao (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The dysregulation of transcription factors is widely associated with tumorigenesis. As the most well-defined transcription factor in multiple types of cancer, c-Myc can transform cells by transactivating various downstream genes. Given that there is no effective way to directly inhibit c-Myc, c-Myc...